Antifibrotic effects of specific siRNA targeting connective tissue growth factor delivered by polyethyleneimine?functionalized magnetic iron oxide nanoparticles on LX?2 cells.
Yu Qin; Xiong Xiaoqin; Zhao Lei; Xu Tingting; Wang Qianhua;
Department of Clinical Laboratory, Wuhan Blood Center, Wuhan, Hubei 430000, P.R. China.; Hubei Key Laboratory of Purification and Application of Plant Anticancer Active Ingredients, School of Chemistry and Life Sciences, Hubei University of Education, Wuhan, Hubei 430205, P.R. China.;Department of Obstetrics and Gynecology, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.;
Connective tissue growth factor (CTGF) is a possible key determinant of progressive fibrosis. Nanotechnology has been considered as a potential tool for developing novel drug delivery systems for various diseases, including liver fibrosis. The present study aimed to investigate the potential antifibrotic activity of CTGF small interfering RNA (siRNA) mediated by polyethyleneimine (PEI)?functionalized magnetic iron oxide (Fe3O4) nanoparticles (NPs) in LX?2 cells. PEI?Fe3O4/siRNA complexes were sy... 更多